Son of the antiquarian William Clarke (1696-1771), Edward Clarke was educated at St. John's College Cambridge (B.A. 1752, M.A. 1755). He was rector of Peperharow, Surrey (1758), chaplain of the embassy to Madrid (1760), chaplain at Minorca (1763-68), and vicar of Willingdon and rector of Buxted, Sussex (1769). Clarke was given the living at Buxted by his father, where he spent his later years pursuing Biblical scholarship.
A letter to a friend in Italy. 1755.
A thanksgiving sermon. 1759.
Letters, concerning the Spanish nation. 1763.
Defence of the Lieutenant-Governor of Minorca. 1767.