The son of a Wexford clergyman of Scottish descent, George Gregory was educated at Liverpool, where he worked as a merchant's clerk and directed a private theater. After study at Edinburgh University (D.D. 1792) he was briefly employed in Liverpool as an Anglican curate. In 1782 Gregory settled in London, publishing essays, sermons, and biographies for the Biographia Britannica; succeeding Kippis, he edited a sixth volume that was destroyed in the fire at the Nichols' warehouse. He was awarded the vicarage of West Ham, supposedly for becoming a writer for the Tory party in the New Annual Register.
A sermon on the lawfulness and expediency of inoculation for the small pox. 1782.
Essays historical and moral. 1785.
The life of Thomas Chatterton, with criticisms on his genius and writings, and a concise view of the controversy concerning Rowley's poems. 1789.
An history of the Christian Church, from the earliest periods to the present time. 2 vols, 1790.
Family prayers for the philanthropic reform; with a short catechism, and an address to the children. 1792.
The economy of nature explained and illustrated on the principles of modern philosophy. 3 vols, 1796.
A sermon on suicide, preached at St. Botolph's Bishopsgate. 1797.
The elements of a polite education, carefully selected from Chesterfield. 1800.
Letters on literature, taste, and composition. 1808.
A dictionary of the arts and sciences. 1808.